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Effect and correction of optode coupling errors in breast imaging using diffuse optical tomography.

Shuying Li1, Kexin Huang1, Menghao Zhang2

  • 1Department of Biomedical Engineering, Washington University in St. Louis, 1 Brookings Dr, St. Louis 63130, USA.

Biomedical Optics Express
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Summary
This summary is machine-generated.

Tissue curvature in diffuse optical tomography (DOT) and spectroscopy (DOS) causes probe errors. We developed an outlier removal algorithm and a force sensor to minimize artifacts and improve image quality for wearable devices.

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Optical Sensing

Background:

  • Handheld diffuse optical tomography (DOT) and spectroscopy (DOS) probes can suffer from poor fiber-to-tissue contact due to tissue curvature.
  • These coupling errors introduce significant image artifacts, degrading the quality of DOT and DOS reconstructions.
  • Improving probe contact is crucial for enhancing the diagnostic accuracy of these optical imaging techniques.

Purpose of the Study:

  • To systematically investigate the impact of source/detector (optode) coupling errors on DOT/DOS measurements.
  • To develop and validate methods for correcting image artifacts caused by poor optode coupling.
  • To introduce a novel sensor for real-time feedback to minimize coupling errors in handheld optical imaging.

Main Methods:

  • Utilized Monte Carlo simulations and phantom experiments to model optode coupling errors.
  • Developed and applied an outlier removal algorithm to correct artifacts in absorption maps.
  • Designed and implemented a thin-film force sensor array for real-time optode coupling feedback.

Main Results:

  • Optode coupling errors were found to alter diffuse reflectance amplitude and phase, creating artifacts like edge hot spots.
  • The proposed outlier removal algorithm effectively corrected simulated and experimental image artifacts.
  • The force sensor array provided real-time feedback, enabling minimization of optode coupling errors.

Conclusions:

  • Optode coupling errors significantly impact DOT/DOS image quality, particularly with handheld probes.
  • An outlier removal algorithm and real-time force feedback sensor can mitigate these artifacts.
  • These advancements are vital for the reliable application of mobile and wearable DOT/DOS devices.