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Oblique injection depth correction by a two parallel OCT sensor guided handheld SMART injector.

Jintaek Im1, Cheol Song1

  • 1Department of Robotics Engineering, DGIST, 333 Techno Jungang-Daero, Daegu, 42988, Republic of Korea.

Biomedical Optics Express
|March 8, 2021
PubMed
Summary

This study introduces a novel subretinal injection system using optical coherence tomography for precise angle measurements and depth control. This advancement aims to improve the accuracy and safety of ophthalmic surgical procedures.

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Surgical Technology

Background:

  • Subretinal injections are crucial for delivering therapies to the retina but require high precision.
  • Oblique injections present challenges in controlling needle angle and depth accurately.
  • Existing methods may lack real-time feedback for precise angle and depth adjustments.

Purpose of the Study:

  • To develop and evaluate a novel subretinal injection system with integrated optical coherence tomography (OCT) for enhanced precision.
  • To enable real-time angle measurements and injection depth corrections during oblique subretinal delivery.
  • To improve the accuracy and safety of subretinal injection procedures.

Main Methods:

  • A subretinal Minimally invasive Angiography and Retinal Tomography (SMART) injector system was designed.
  • Two parallel common-path OCT fibers were integrated with a 33 G needle passing through a 23 G trocar.
  • The system was calibrated using a rotational stage, and performance was evaluated in an eye model, agarose gel phantom, and porcine eye.

Main Results:

  • The SMART injector demonstrated the capability for angle measurements and injection depth corrections.
  • Calibration on a rotational stage minimized angular measurement errors.
  • Successful injection experiments were conducted in various models, validating the system's control performance.

Conclusions:

  • The developed SMART injector system with OCT offers a promising solution for precise oblique subretinal injections.
  • Real-time angle and depth feedback can significantly improve the accuracy and safety of subretinal delivery.
  • This technology has the potential to enhance therapeutic outcomes in retinal diseases.