Serum neuron-specific enolase in senile dementia of the Alzheimer type

The level of neuron-specific enolase (NSE), a glycolytic enzyme localized in neurons, was measured in the serum of patients with senile dementia of the Alzheimer type (SDAT). No difference was observed between NSE levels in SDAT and in healthy elderly controls of the same age range. No correlation was found between NSE levels and severity of the cognitive deficits. There was a marginally significant negative correlation between age and NSE, younger patients having higher NSE levels. The present results suggest that serum NSE is not a useful biological marker in the senile form of the dementia of the Alzheimer type.