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"Smart" Polymer Nanogels as Pharmaceutical Carriers: A Versatile Platform for Programmed Delivery and Diagnostics
Namitha K Preman1, Supriya Jain1, Renjith P Johnson1
1Polymer Nanobiomaterial Research Laboratory, Nanoscience and Microfluidics Division, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, Karnataka 575018, India.
ACS Omega
|March 8, 2021
Summary
Smart polymer nanogels (NGs) offer advanced theranostic capabilities, enabling triggered delivery and monitoring of treatments. This review covers their synthesis, applications, and clinical challenges for future development.
Area of Science:
- Polymer science and nanotechnology
- Biomedical engineering
- Materials science
Background:
- Smart polymeric nanoformulations are emerging as powerful tools for simultaneous diagnosis and therapy (theranostics).
- Polymeric nanovehicles, particularly polymer nanogels (NGs), excel at encapsulating and delivering diverse therapeutic and diagnostic agents.
- Intelligent, biodegradable NGs respond to various stimuli, enhancing targeted delivery and therapeutic monitoring.
Purpose of the Study:
- To review synthesis strategies for "smart" polymer nanogels (NGs).
- To summarize the applications of NGs in theranostic applications.
- To discuss the current clinical status and future challenges of NGs.
Main Methods:
- Review of recent literature on "smart" polymer nanogels.
- Analysis of synthesis methods for stimuli-responsive NGs.
- Compilation of applications in drug delivery, imaging, and biosensing.
Main Results:
- "Smart" NGs demonstrate high efficacy in delivering genetic materials and anticancer agents.
- Applications include photodynamic/photothermal therapies, advanced imaging, and sensitive biosensing.
- Significant progress has been made in developing multifunctional NGs with enhanced targetability and sensitivity.
Conclusions:
- "Smart" polymer nanogels represent a versatile platform for advanced theranostic applications.
- Overcoming current clinical and technical challenges is crucial for widespread adoption.
- Further research into stimuli-responsive NGs will drive innovation in personalized medicine.
