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Sex as a Risk Factor for Developing Cognitive Impairments in National Alzheimer's Coordinating Center Participants
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background:
It is inconclusive on how sex affects the risk of developing mild cognitive impairment (MCI) or dementia.
Objective:
To investigate how sex affects the risk of developing MCI or dementia.
Methods:
A secondary data analysis was performed on data collected from participants enrolled at Alzheimer's Disease Research Centers funded by National Institute on Aging. There were two inclusion criteria: 1) participants were free of dementia at the baseline visit; 2) every participant must have at least one follow-up visit. A Cox proportional hazards model was used to investigate how sex affects the risk of developing cognitive impairments.
Results:
During a follow-up period of more than 10 years, male participants had a slightly higher incidence than female participants for either MCI or dementia. Not surprisingly, a higher prevalence was observed in male than female participants for either MCI or dementia. However, male participants had a higher mortality rate than their female counterparts.
Conclusion:
The male sex is associated with a higher risk for developing cognitive impairments along the aging process.