Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice.

EMBO molecular medicine·2026

Same author

Senolytic Changes in Murine Arteriovenous Fistulas with CKD.

Kidney360·2026

Same author

Mitochondrial RNA cytosolic leakage drives the SASP.

Nature communications·2025

Same author

Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues.

The EMBO journal·2025

Same author

Boat noise alters behaviour of two coral reef macroinvertebrates, Lambis lambis and Tridacna maxima.

Marine pollution bulletin·2025

Same author

Deep Learning in Scaphoid Nonunion Treatment.

Journal of clinical medicine·2025

Search research articles

Related Experiment Video

Updated: Nov 14, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

C-reactive protein in spinal surgery: more predictive than prehistoric.

S Hoeller¹, P J Roch¹, L Weiser¹

¹Department of Trauma, Orthopedics and Reconstructive Surgery, Georg-August-University of Goettingen, Robert-Koch-Straße 40, 37075, Goettingen, Germany.

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

|March 8, 2021

Summary

Postoperative C-reactive protein (CRP) levels after spinal surgery can predict surgical site infections (SSI). Monitoring CRP kinetics, specifically a second peak or failure to decline, aids in early SSI detection following dorsal spondylodesis.

Keywords:

C-reactive protein Dorsal spondylodesis Revision surgery Spinal surgery Surgical site infection

More Related Videos

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

Evaluation of Patients' Posture and Gait Profile After Lumbar Fusion Surgery by Video Rasterstereography and Treadmill Gait Analysis

Published on: March 23, 2019

Related Experiment Videos

Last Updated: Nov 14, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

Evaluation of Patients' Posture and Gait Profile After Lumbar Fusion Surgery by Video Rasterstereography and Treadmill Gait Analysis

Published on: March 23, 2019

Area of Science:

Orthopedics
Infectious Disease
Biochemistry

Background:

Surgical site infections (SSI) are serious complications following spinal surgery, particularly dorsal spondylodesis.
Early and accurate detection of postoperative SSI is critical for patient outcomes.

Purpose of the Study:

To evaluate the prognostic value of C-reactive protein (CRP) kinetics in predicting SSI after open reduction and dorsal spondylodesis.
To identify specific CRP patterns indicative of infectious complications.

Main Methods:

Retrospective cohort study of 192 patients undergoing dorsal spondylodesis from 2016-2018.
Analysis of serological and clinical characteristics, focusing on CRP levels for 20 days post-surgery.
Statistical analysis including binary logistic regression and one-phase decay exponential regression.

Main Results:

Significantly higher CRP levels were observed on postoperative days 7 and 8 in patients who developed SSI.
A second CRP peak, failure to decline, and a maximum CRP >225 mg/l predicted SSI with high sensitivity (92.9%) and specificity (78.2%).
Regression models demonstrated predictive capabilities for infectious complications.

Conclusions:

Postoperative CRP kinetics are highly valuable for detecting SSI after dorsal spondylodesis.
Specific CRP level patterns can facilitate early SSI detection in clinical practice.
This monitoring approach can improve patient management and outcomes.