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Peritoneal macrophage is the cell transformed by Yoshida ascites tumor virus
1Institute of General Pathology, University of Messina, Italy.
Oncology
|January 1, 1988
Abstract:
Resident peritoneal macrophages purified by adhesion on plastic surface, suspended in 1 ml of cell-free fluid from Yoshida ascites tumor for 2 h, washed three times and reinjected in the original rat, produce the development of a neoplasia with the same properties as the Yoshida ascites tumor.
Insights
Resident peritoneal macrophages, when exposed to Yoshida ascites tumor fluid and reinjected, induced neoplasia development. This study explores the tumor-promoting capacity of peritoneal macrophages in rats.
Area of Science:
- Oncology
- Cell Biology
- Immunology
Background:
- Peritoneal macrophages are key immune cells in the abdominal cavity.
- The Yoshida ascites tumor is a well-characterized experimental tumor model.
- Understanding the role of macrophages in tumor development is crucial.
Purpose of the Study:
- To investigate the potential of resident peritoneal macrophages to induce tumor development.
- To determine if macrophages exposed to tumor ascites fluid acquire neoplastic properties.
Main Methods:
- Resident peritoneal macrophages were isolated and purified.
- Macrophages were incubated in Yoshida ascites tumor cell-free fluid.
- The treated macrophages were reinjected into syngeneic rats.
Main Results:
- Reinjection of treated macrophages led to the development of neoplasia.
- The induced tumors exhibited properties identical to the original Yoshida ascites tumor.
Conclusions:
- Resident peritoneal macrophages can be induced to promote neoplasia development.
- Exposure to Yoshida ascites tumor fluid confers tumor-promoting properties to macrophages.