Related Experiment Video

Updated: Nov 14, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

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Role of the runt-related transcription factor (RUNX) family in prostate cancer

Hannah Ashe1, Patryk Krakowiak1, Sylwia Hasterok1

  • 1Departments of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA.

The FEBS Journal
|March 8, 2021
PubMed

Insights

Runt-related transcription factors (RUNX) drive castration-resistant prostate cancer (CRPC) progression, necessitating novel therapeutic strategies beyond androgen receptor antagonism. Targeting RUNX proteins offers potential for more durable treatments and new biomarkers for prostate cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer (PCa) is a leading cause of cancer-related death in men globally.
  • Current treatments targeting the androgen receptor (AR) axis are often limited by the development of castration-resistant prostate cancer (CRPC) within 2-3 years.
  • There is a critical need for more effective and durable therapies for advanced PCa.

Purpose of the Study:

  • To review the current understanding of runt-related transcription factors (RUNX) in prostate cancer.
  • To explore the role of RUNX proteins in PCa progression, AR signaling, and the tumor microenvironment.
  • To discuss the therapeutic and biomarker potential of RUNX proteins in CRPC.

Main Methods:

  • Literature review of studies investigating RUNX family members in prostate cancer.
  • Analysis of the regulatory networks and downstream targets of RUNX proteins.
  • Examination of the role of RUNX in the context of the tumor microenvironment and androgen receptor signaling.

Main Results:

  • RUNX family members are increasingly recognized as key drivers of CRPC.
  • RUNX proteins influence AR signaling and are implicated in the tumor microenvironment.
  • Understanding RUNX regulation and targets is crucial for deciphering CRPC pathogenesis.

Conclusions:

  • RUNX proteins represent promising therapeutic targets for overcoming castration resistance in prostate cancer.
  • RUNX family members hold potential as biomarkers for predicting PCa progression and treatment response.
  • Further research is needed to fully elucidate the complex roles of RUNX in PCa and to develop targeted therapies.
Keywords:
ARCBF betaRUNXprostate cancertranscription factor

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