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Evaluating Phospholipid-Functionalized Gold Nanorods for In Vivo Applications.

Lucien Roach1, Mary E Booth2, Nicola Ingram2

  • 1School of Physics and Astronomy, University of Leeds, Leeds, LS2 9JT, UK.

Small (Weinheim an Der Bergstrasse, Germany)
|March 8, 2021
PubMed
Summary

Researchers developed a new method to remove toxic chemicals from gold nanorods (AuNRs) using phospholipids. This makes AuNRs safer and more stable for biomedical applications, including photothermal therapy.

Keywords:
biocompatibilitygold nanorodsin vivophospholipidsstability

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • Gold nanorods (AuNRs) show promise for biomedical uses.
  • CTAB surfactant used in AuNR production is toxic for in vivo applications.
  • Detoxification protocols for AuNRs are needed.

Purpose of the Study:

  • To present a method for removing CTAB from AuNRs.
  • To evaluate the stability and biocompatibility of detoxified AuNRs.
  • To assess the suitability of functionalized AuNRs for plasmonic medical applications.

Main Methods:

  • Displacement of CTAB using phospholipids.
  • Characterization using NMR spectroscopy, SERS, and ζ-potential measurements.
  • Biocompatibility testing (IC50) and in vivo studies.

Main Results:

  • CTAB was undetectable after phospholipid treatment.
  • Phospholipid-functionalized AuNRs showed enhanced stability and biocompatibility (IC50 > 200 µg mL-1).
  • AuNRs were well tolerated in vivo and exhibited high NIR absorbance for photothermal applications.

Conclusions:

  • Phospholipid functionalization offers a robust detoxification strategy for AuNRs.
  • Detoxified AuNRs are suitable for in vivo biomedical applications.
  • This method enhances AuNR safety and efficacy in plasmonic therapies.