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The Indiana O'Brien Center for Advanced Renal Microscopic Analysis
Kenneth W Dunn1, Bruce A Molitoris1, Pierre C Dagher1
1Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
American Journal of Physiology. Renal Physiology
|March 8, 2021
Summary
The Indiana O'Brien Center advances renal research globally by developing and sharing cutting-edge optical microscopy techniques, including intravital multiphoton microscopy and tissue cytometry.
Area of Science:
- Microscopy
- Renal Research
- Biomedical Imaging
Background:
- The Indiana O'Brien Center, established in 2002, is a National Institutes of Health (NIH) P30-funded center.
- Initially focused on intravital multiphoton microscopy for renal studies, its scope has broadened.
- The center supports global renal researchers through advanced imaging methods.
Purpose of the Study:
- To develop and disseminate advanced optical microscopy techniques.
- To support the understanding of renal physiology and pathophysiology.
- To implement large-scale, high-content tissue cytometry.
Main Methods:
- Development of advanced optical microscopy methods.
- Application of intravital multiphoton microscopy.
- Implementation of high-content tissue cytometry.
Main Results:
- Expanded capabilities beyond initial intravital multiphoton microscopy.
- Established large-scale, high-content tissue cytometry.
- Provided global access to advanced imaging through collaborations and fellowships.
Conclusions:
- The center is a key resource for renal researchers worldwide.
- Advanced imaging technologies are crucial for understanding kidney function and disease.
- Dissemination of techniques through training and outreach enhances research capacity.