Saving Science Through Replication Studies
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Updated: Nov 14, 2025

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
Published on: June 29, 2018
John E Edlund1, Kelly Cuccolo2, Megan S Irgens3
1Department of Psychology, Rochester Institute of Technology.
Abstract:
The scientific enterprise has long been based on the presumption of replication, although scientists have recently become aware of various corruptions of the enterprise that have hurt replicability. In this article, we begin by considering three illustrations of research paradigms that have all been subject to intense scrutiny through replications and theoretical concerns. The three paradigms are one for which the corpus of research points to a real finding, one for which the corpus of research points to a significantly attenuated effect, and one for which the debate is ongoing. We then discuss what scientists can learn-and how science can be improved-through replications more generally. From there, we discuss what we believe needs to be done to improve scientific inquiry with regard to replication moving forward. Finally, we conclude by providing readers with several different approaches to replication and how these approaches progress science. The approaches discussed include multilab replications of many effects, multilab replications of specific effects, adversarial collaborations, and stand-alone applications.
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