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Bilateral periorbital leukemia cutis presenting as suspected cellulitis
Lalita Gupta1, Melissa A Levoska2, Timmie Sharma2
1Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Orbit (Amsterdam, Netherlands)
|March 8, 2021
Summary
Periorbital edema and erythema can mimic infections but may signal leukemia cutis in patients with acute myeloid leukemia (AML). Targeted therapy with enasidenib effectively treated this rare AML manifestation.
Area of Science:
- Hematology
- Dermatology
- Oncology
Background:
- Periorbital edema and erythema are common symptoms that can mimic preseptal cellulitis.
- Acute myeloid leukemia (AML) can present with unusual cutaneous manifestations.
Observation:
- A patient with relapsed monoblastic mutant isocitrate dehydrogenase-2 (IDH2) AML presented with periorbital edema and erythema.
- Symptoms were unresponsive to antibiotic treatment.
Findings:
- Histopathology confirmed leukemia cutis, a leukemic infiltration of the skin.
- The patient showed a rapid clinical response to enasidenib, a targeted inhibitor of mutant IDH2.
Implications:
- This case underscores the importance of considering leukemia cutis in AML patients with periorbital symptoms.
- Early recognition and targeted therapy can lead to favorable outcomes in rare AML presentations.
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