Toxicity of Somadril Compound on Fetal Ileum Tissues of Albino Rats

Carisoprodol is a relaxant muscular-skeleton associated with sore muscles and appropriate studies have not been performed on carisoprodol effects on fetuses and mothers. This study has been conducted to clarify the treatment with a high and low dosage of carisoprodol (Somadril) on the histopathological, histochemical changes in the fetal ileum of the Albino rats.

In the present research 30 adult pregnant rats have been used and divided into three classes (10 pregnant rats in each group), the first group was the group of Control (C). The 2nd and 3rd groups (S1 and S2) were treated with carisoprodol oral doses equating to 10.8 and 21.6 mg/100 g b.wt. per day, respectively. For 15 days from day 6-20 of pregnancy, groups S1 and S2 are administered. On the 20th day of pregnancy, the pregnant rats were sacrificed and small parts of fetal ileum for histopathological and histochemical studies.

Diverse histopathological and histochemical alternations were detected in the fetal ileum tissue of the two groups S1 and S2 after maternal treatment with high and low doses of carisoprodol compared to the control set.

This study showed that several histopathological and histochemical deformities in the fetal ileum tissues were caused by the administration of carisoprodol.