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Mohs Micrographic Surgery for Genital Skin Cancer: A Review of Cases and Reconstructive Techniques
Abstract:
As the incidence of non-melanoma skin cancer (NMSC) increases in the United States, one area of particular concern is NMSC arising on the genitalia. In the past, most genital skin tumors have been treated by conventional radical surgical approaches such as penectomy, vulvectomy, or wide local excision. In recent years, tissue sparing Mohs micrographic surgery (MMS) has been established as a safe and effective method of achieving cutaneous genital tumor clearance. The aim of this article is to provide an overview of NMSCs arising on genital skin treated with MMS, and describe some of their indications, results, and associated complications. A summary of case reports, case series, and retrospective reviews is made available to guide decision making and surgical planning for tumors of this nature. Pertinent anatomy, site-specific surgical techniques, and reconstruction options of genital skin will be discussed. J Drugs Dermatol. 2021;20(3):311-319. doi:10.36849/JDD.5656.
Insights
Mohs micrographic surgery (MMS) offers a safe and effective approach for treating non-melanoma skin cancer (NMSC) on the genitalia. This tissue-sparing technique provides excellent tumor clearance while preserving delicate genital structures.
Area of Science:
- Dermatology
- Surgical Oncology
Background:
- Non-melanoma skin cancer (NMSC) incidence is rising, with genital NMSC posing a particular challenge.
- Traditional treatments like penectomy or vulvectomy are radical and can impact function and aesthetics.
Purpose of the Study:
- To review the use of Mohs micrographic surgery (MMS) for NMSC on genital skin.
- To discuss indications, outcomes, complications, and surgical techniques for MMS in this sensitive area.
Main Methods:
- Review of case reports, case series, and retrospective studies on genital NMSC treated with MMS.
- Discussion of relevant anatomy, surgical techniques, and reconstruction options.
Main Results:
- MMS is established as a safe and effective method for genital NMSC clearance.
- The article provides guidance for surgical planning and decision-making.
Conclusions:
- MMS is a valuable tissue-sparing option for genital NMSC.
- Understanding site-specific techniques and reconstruction is crucial for optimal patient outcomes.

