Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Dual-photon absorptiometry: a new method of determining bone mineral content. I. Basic principles].

G Buttermann1, J Eiber, J Hennig

  • 1Nuklearmedizinische Klinik der Technischen Universität München, BRD.

Nuklearmedizin. Nuclear Medicine
|February 1, 1988
PubMed
Summary

Dual-photon absorptiometry (DPA) is a reliable method for early osteoporosis diagnosis. However, "normal" bone mineral content (BMC) values vary significantly, complicating individual risk assessment, especially in postmenopausal women.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for Subsolar-Mass Binaries in the First Half of Advanced LIGO's and Advanced Virgo's Third Observing Run.

Physical review letters·2022
Same author

Constraints on Cosmic Strings Using Data from the Third Advanced LIGO-Virgo Observing Run.

Physical review letters·2021
Same author

Prospects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.

Living reviews in relativity·2020
Same author

GW190521: A Binary Black Hole Merger with a Total Mass of 150  M_{⊙}.

Physical review letters·2020
Same author

Characterization of transient noise in Advanced LIGO relevant to gravitational wave signal GW150914.

Classical and quantum gravity·2020
Same author

GW150914: First results from the search for binary black hole coalescence with Advanced LIGO.

Physical review. D. (2016)·2020

Area of Science:

  • Bone Densitometry
  • Osteoporosis Diagnosis
  • Medical Imaging

Background:

  • Dual-photon absorptiometry (DPA) is currently recommended for early osteoporosis detection due to its cost-effectiveness, low radiation, and reliability.
  • Assessing bone mineral content (BMC) is crucial for diagnosing and monitoring bone diseases.

Purpose of the Study:

  • To evaluate the effectiveness of DPA in determining bone mass in a cohort of males and females.
  • To identify the most suitable parameter for longitudinal and cross-sectional bone mass studies.
  • To address challenges in individual fracture risk assessment using DPA.

Main Methods:

  • Dual-photon absorptiometry (DPA) using 153Gd was employed to measure cortical and trabecular bone mass.
  • Bone mineral content (BMC) and BMC-area were determined in 545 females and 112 males.

Related Experiment Videos

  • Measured "normal" values were compared with US inhabitants and Belgian data.

    • Main Results:

    • "Normal" BMC values in the study cohort were approximately 30% lower than those of US inhabitants but consistent with Belgian data.
    • BMC-area was identified as the most suitable parameter for both cross-sectional and longitudinal studies, being independent of height and weight.
    • Significant overlap in "normal" BMC values and wide variations, particularly in women due to menopause, complicate individual fracture risk assessment.

    Conclusions:

    • While DPA is valuable for osteoporosis diagnosis, improvements in accuracy and reproducibility are needed for shorter-interval assessments.
    • Individual fracture risk estimation requires careful consideration of the wide range of "normal" BMC values and menopausal status.
    • Normalizing BMC on age for elderly patients may lead to misclassification; comparing postmenopausal values to premenopausal averages or age-normalized values could be more informative.