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Related Experiment Video

Updated: Nov 14, 2025

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

Published on: August 25, 2018

E-cigarette users are associated with asthma disease: A meta-analysis.

Shaojing Xian¹, Yongxing Chen¹

¹Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.

The Clinical Respiratory Journal

|March 8, 2021

Summary

Electronic cigarette use, both current and former, is linked to an increased risk of asthma. This association was particularly notable in adults and females, and when e-cigarettes were used with traditional cigarettes.

Keywords:

asthma e-cigarettes meta-analysis smoking

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Area of Science:

Pulmonology
Public Health
Epidemiology

Background:

Over 300 million individuals worldwide suffer from asthma.
Electronic cigarettes (e-cigarettes) are increasingly popular, especially among younger demographics.
The link between e-cigarette use and asthma risk remains a subject of debate.

Purpose of the Study:

To conduct a meta-analysis investigating the association between e-cigarette use and asthma risk.
To synthesize existing research to provide a clearer understanding of this relationship.

Main Methods:

A comprehensive literature search was performed across PubMed, Embase, and Web of Science for studies published before August 2020.
Data analysis was conducted using R version 3.6.3.
Publication bias was evaluated using funnel plots, Begg's rank correlation test, and Egger regression asymmetry tests, with adjustments for confounding factors in most included studies.

Main Results:

E-cigarette use demonstrated a significant association with asthma (OR = 1.27, 95% CI = 1.17-1.37).
Both current (OR = 1.30, 95% CI = 1.17-1.45) and former e-cigarette use (OR = 1.22, 95% CI = 1.08-1.39) were linked to asthma.
Combined e-cigarette and traditional cigarette use showed a higher association with asthma (OR = 1.47, 95% CI = 1.13-1.91) compared to traditional cigarette use alone (OR = 1.33, 95% CI = 1.19-1.49).
Subgroup analyses indicated a stronger association in adult and female e-cigarette users.

Conclusions:

This meta-analysis concludes that both current and former e-cigarette use are associated with an increased prevalence of asthma.
Further research with more rigorous study designs is warranted to definitively establish the specific relationship between e-cigarette use and asthma.