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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
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Fetomaternal immune cross talk modifies T-cell priming through sustained changes to DC function.

Matthew Lacorcia1, Sonakshi Bhattacharjee1, Kristina Laubhahn2

  • 1Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany.

The Journal of Allergy and Clinical Immunology
|March 8, 2021
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Summary

Maternal schistosomiasis infection during pregnancy alters offspring immune responses, skewing allergic reactions and impacting vaccine efficacy against viral infections. These effects persist into adulthood due to altered immune cell programming.

Keywords:
Fetomaternal cross talkdendritic cellsearly-life determinants of allergy and immune diseaseimmune primingimmunoregulationinnate memoryschistosomiasis

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Area of Science:

  • Immunology
  • Developmental Biology
  • Infectious Diseases

Background:

  • Prenatal exposure to infections can significantly influence immune system development.
  • Early-life environmental disturbances may increase susceptibility to inflammatory disorders and affect immune responses.
  • Schistosoma mansoni infection is known to modulate immune responses, impacting coinfections, allergies, and vaccine effectiveness.

Purpose of the Study:

  • To investigate the long-term effects of maternal schistosomiasis on offspring immune responses.
  • To clarify the immunologic imprinting resulting from prenatal exposure to helminth infection.
  • To examine how maternal infection influences allergic sensitization and vaccine responses in offspring.

Main Methods:

  • Utilized a murine model of chronic maternal schistosomiasis.
  • Analyzed offspring immune responses to allergy and vaccination models.
  • Included viral challenge and assessment of immune cell compartments.

Main Results:

  • Maternal schistosomiasis induced a skewed IL-4/B-cell-dominant response to allergic sensitization and challenge.
  • Offspring exhibited altered CD8+ T-cell responses to immunization, affecting vaccine efficacy against viral infection.
  • Identified modifications in CD4+ T-cell polarization and B-cell priming in offspring.

Conclusions:

  • Maternal schistosomiasis leads to lasting immune alterations in offspring, including skewed T-cell responses and impaired vaccine effectiveness.
  • Modified CD8+ T-cell responses were linked to altered dendritic cell phenotypes persisting into adulthood.
  • Fetomaternal cross-talk during infection establishes complex immune imprinting with long-term consequences.