Related Experiment Videos
In vitro transformation of cheno- and ursodeoxycholic acids and their 7-oleyl esters by human intestinal microflora
A Ferrari1, N Pacini, C R Sirtori
1Department of Food Science and Microbiology, University of Milan, Italy.
Abstract:
Chenodeoxycholic and ursodeoxycholic acid are used widely for the treatment of gallstones. A possible drawback to their utility is their conversion to lithocholic acid, which has displayed histotoxicity and mutagenicity. The 7-oleyl esters of cheno- and ursodeoxycholic acid are not degraded by fecal bacteria and may represent safer means of treatment.