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Metabolism of 14C-rhein and 14C-rhein anthrone in rats
1Laboratorie voor Farmaceutische Biologie en Fytofarmacologie, Katholieke Universiteit, Leuven, Belgium.
Pharmacology
|January 1, 1988
Abstract:
The two radioactive compounds were administered intracaecally to rats, and the recovery rates amounted to 89.9% for 14C-rhein and to 97.4% for 14C-rhein anthrone after 5 days. All organs and tissues showed for both compounds a significant clearance of radioactivity with exception of the kidneys where high levels persisted even after 5 days. Different metabolites could be detected in urine as well as in faeces where also nonanthraquinone fractions could be found.