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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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Related Experiment Video

Updated: Nov 14, 2025

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

Spatial profiling technologies and applications for brain cancers.

Priyakshi Kalita-de Croft¹, Habib Sadeghi Rad², Harry Gasper^3,4

¹UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.

Expert Review of Molecular Diagnostics

|March 9, 2021

Summary

This summary is machine-generated.

Spatial transcriptomics advances brain cancer research by detailing the complex tumor microenvironment (TME). Understanding the TME aids in developing new therapies and overcoming treatment resistance in brain tumors.

Keywords:

Brain tumors brain metastasis glioblastoma spatial profiling tumor microenvironment

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Last Updated: Nov 14, 2025

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Area of Science:

Neuro-oncology
Cancer Biology
Genomics

Background:

Malignant primary and secondary brain tumors present a growing health challenge.
The brain tumor microenvironment (TME) is complex and influences treatment outcomes.
Rising incidence necessitates advanced research methods for brain cancers.

Purpose of the Study:

To review cutting-edge spatial profiling technologies.
To highlight applications of these technologies in brain cancer research.
To enhance understanding of the brain tumor microenvironment.

Main Methods:

Overview of spatial transcriptomics and related imaging technologies.
Discussion of multi-omics approaches for tissue analysis.
Review of current literature on spatial profiling in brain tumors.

Main Results:

Spatial transcriptomics offers deep insights into tissue architecture and cellular profiles.
These technologies reveal cellular activation states within the TME.
Characterization of the heterogeneous and immunosuppressive brain TME is enabled.

Conclusions:

Next-generation imaging and multi-omics tools are crucial for characterizing brain tumor biology.
Understanding tissue biology aids in designing effective cancer therapies.
These advancements are key to addressing therapy resistance in brain tumors.