High sensitivity troponin and COVID-19 outcomes
Nikolaos Papageorgiou1,2, Catrin Sohrabi1, David Prieto Merino3,4
1St. Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
Elevated troponin levels in COVID-19 patients indicate myocardial injury and predict adverse outcomes, including increased need for ventilation and higher mortality risk. These findings suggest troponin testing can aid in managing COVID-19 patients.
Area of Science:
- Cardiology
- Infectious Diseases
- Critical Care Medicine
Background:
- Recent studies highlight elevated troponin levels in COVID-19 patients.
- Myocardial injury is a significant concern in COVID-19 pathophysiology.
Purpose of the Study:
- To investigate the association between admission and peak troponin levels and COVID-19 outcomes.
- To determine the predictive value of troponin for adverse events in COVID-19 patients.
Main Methods:
- Observational, multi-ethnic, multi-center study of 434 COVID-19 positive patients in London, UK.
- Data collected during the second half of March 2020.
Main Results:
- Myocardial injury (positive troponin) observed in 66.4% of patients.
- Positive peak troponin levels independently predicted need for ventilation, renal replacement therapy, acute kidney injury, venous thromboembolism, atrial fibrillation, and in-hospital death.
- Patients with elevated troponin had longer hospital stays.
Conclusions:
- Admission and peak troponin levels are significant predictors of cardiovascular and non-cardiovascular outcomes in COVID-19.
- Troponin level assessment can inform patient management strategies for COVID-19.
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