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Long Noncoding RNAs at the Crossroads of Cell Cycle and Genome Integrity
Giulia Guiducci1, Lovorka Stojic1
1Barts Cancer Institute, Centre for Cancer Cell and Molecular Biology, John Vane Science Centre, Charterhouse Square, Queen Mary University of London, London EC1M 6BQ, UK.
Trends in Genetics : TIG
|March 9, 2021
Summary
Long noncoding RNAs (lncRNAs) regulate cell cycle control and genome stability. Dysregulation of lncRNA networks contributes to diseases like cancer, highlighting their crucial role in cellular health.
Area of Science:
- Molecular Biology
- Genetics
- Cell Biology
Background:
- Cell cycle progression is tightly regulated by proteins to ensure genome stability.
- Genome instability is linked to various human diseases, including cancer.
- Long noncoding RNAs (lncRNAs) are emerging as critical regulators beyond protein-coding genes.
Purpose of the Study:
- To review the multifaceted roles of lncRNAs in cell cycle regulation.
- To explore the involvement of lncRNAs in maintaining genome integrity.
- To discuss the implications of lncRNA dysregulation in proliferative diseases.
Main Methods:
- Literature review of studies on lncRNAs and cell cycle control.
- Analysis of mechanisms by which lncRNAs influence cellular processes.
- Synthesis of evidence linking lncRNA networks to disease pathogenesis.
Main Results:
- lncRNAs actively participate in cell cycle control and genome stability.
- lncRNAs employ diverse mechanisms to regulate gene expression and cellular functions.
- Altered lncRNA regulatory networks are associated with uncontrolled cell proliferation.
Conclusions:
- lncRNAs are essential players in safeguarding the cell cycle and genome integrity.
- Understanding lncRNA functions provides insights into disease mechanisms.
- Targeting lncRNA networks may offer therapeutic strategies for cancer.
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