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Differences in Primary Hyperparathyroidism Between Pre- and Postmenopausal Women in India
Ashutosh Kumar Arya1, Sanjay Kumar Bhadada1, Poonam Kumari1
1Departments of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Summary
Premenopausal women with primary hyperparathyroidism (PHPT) generally present with more severe symptoms and biochemical markers. However, postmenopausal PHPT cases are increasing, indicating a growing concern in this demographic.
Area of Science:
- Endocrinology
- Women's Health
- Metabolic Bone Disease
Background:
- Primary hyperparathyroidism (PHPT) is a common endocrine disorder, particularly in postmenopausal women.
- Understanding demographic and clinical differences is crucial for effective management.
Purpose of the Study:
- To compare demographic, clinical, and biochemical characteristics of premenopausal and postmenopausal women with PHPT.
- To analyze trends in PHPT prevalence based on menopausal status.
Main Methods:
- Retrospective analysis of women with PHPT from an Indian registry (2005-2019).
- Comparison of premenopausal (pre-M) and postmenopausal (post-M) patient cohorts.
Main Results:
- Premenopausal women had higher rates of symptomatic disease, osteitis fibrosa cystica, higher PTH, and alkaline phosphatase levels.
- Postmenopausal women showed increased prevalence of hypertension and gallstone disease.
- A significant increase in postmenopausal PHPT cases was observed between 2015-2019 compared to 2005-2009.
Conclusions:
- While PHPT is more prevalent in premenopausal women, postmenopausal cases are rising.
- Premenopausal women typically exhibit more severe clinical and biochemical manifestations of PHPT.
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