Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

8.1K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
8.1K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

13.5K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
13.5K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

2.2K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CGE26-139: Genomic Signatures of CNS and Systemic Relapse in Diffuse Large B-Cell Lymphoma (DLBCL) Patients Profiled With Next Generation Sequencing (NGS).

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

CGE26-139: Genomic Signatures of CNS and Systemic Relapse in Diffuse Large B-Cell Lymphoma (DLBCL) Patients Profiled With Next Generation Sequencing (NGS).

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

Molecular Characterization of <italic>MECOM</italic> Rearrangements in Two Cases with Myelodysplastic Syndrome and t(2;3)(p23;q26.2).

Cytogenetic and genome research·2025
Same author

DeepHeme, a high-performance, generalizable deep ensemble for bone marrow morphometry and hematologic diagnosis.

Science translational medicine·2025
Same author

Diagnostic Approach to Myeloproliferative Neoplasms and Myelodysplastic/Myeloproliferative Neoplasms.

Advances in anatomic pathology·2025
Same author

KIT Inhibitor Therapy in a Pediatric Patient With Systemic Mastocytosis and a Germ Cell Tumor of Shared Clonal Origin.

Pediatric blood & cancer·2025

Related Experiment Video

Updated: Nov 14, 2025

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

552

New developments in non-Hodgkin lymphoid malignancies.

Karthik A Ganapathi1, Laura E Brown1, Sonam Prakash1

  • 1Department of Laboratory Medicine, University of California San Francisco, CA, USA.

Pathology
|March 9, 2021
PubMed
Summary

The 2017 WHO classification updates B-cell and T-cell non-Hodgkin lymphomas, incorporating genetic insights and refining diagnoses for various lymphomas like diffuse large B-cell lymphoma and intestinal T-cell lymphomas.

Keywords:
2017 World Health Organization ClassificationEBV-positive mucocutaneous ulcerNOSanaplastic large cell lymphoma ALK–breast implant-associated anaplastic large cell lymphomadiagnostic criteriahigh grade B-cell lymphomain situ follicular neoplasiaindolent mantle cell lymphomalarge B-cell lymphoma with IRF4 rearrangementmonoclonal B-cell lymphocytosismonomorphic epitheliotropic intestinal T-cell lymphoma

More Related Videos

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.4K
Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
08:17

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

21.6K

Related Experiment Videos

Last Updated: Nov 14, 2025

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

552
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.4K
Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
08:17

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

21.6K

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • The World Health Organization (WHO) Classification of Tumours of Haematopoietic and Lymphoid Tissues is crucial for diagnosing and understanding blood cancers.
  • Significant advancements in molecular biology and genetics necessitate regular updates to this classification.

Purpose of the Study:

  • To review major changes in the 2017 WHO classification of B-cell and T-cell non-Hodgkin lymphomas.
  • To highlight recent updates and their impact on diagnosis and understanding of these neoplasms.

Main Methods:

  • Analysis of the revised fourth edition of the WHO Classification (2017).
  • Inclusion of recent updates and findings beyond the 2017 publication.
  • Focus on genetic aberrations, immunohistochemical evaluation, and clinicopathological features.

Main Results:

  • The 2017 WHO classification shows conservatism in precursor lesions but recognizes new entities with recurrent genetic aberrations (e.g., Burkitt-like lymphoma with 11q aberration).
  • Diagnostic workup refined by mutations (MYD88 L265P, BRAF V600E) for lymphoplasmacytic lymphoma and hairy cell leukaemia.
  • Updates include renaming EBV-positive large B-cell lymphoma, introducing EBV-positive mucocutaneous ulcer, and reclassifying intestinal T-cell lymphomas (e.g., monomorphic epitheliotropic T-cell lymphoma).
  • Aggressive lymphomas with specific rearrangements ('double-hit/triple-hit') are now a distinct entity.
  • Anaplastic large cell lymphoma, ALK-negative, is a definitive entity, with new provisional entities like breast implant-associated ALCL and primary cutaneous acral CD8-positive T-cell lymphoma.

Conclusions:

  • The 2017 WHO classification and subsequent updates reflect a deeper understanding of lymphoma biology, driven by genetic discoveries.
  • These revisions impact diagnostic criteria, classification of specific entities, and understanding of disease behavior.
  • The ongoing evolution of lymphoma classification underscores the importance of integrating molecular and pathological findings for accurate diagnosis and patient care.