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Membrane traffic related to endosome dynamics and protein secretion in filamentous fungi

Yujiro Higuchi1

  • 1Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.

Bioscience, Biotechnology, and Biochemistry
|March 9, 2021
PubMed

Insights

This review explores membrane traffic in filamentous fungi, focusing on early endosome (EE) dynamics and protein secretion. Understanding these processes is key for fungal cell factory applications.

Area of Science:

  • Cell Biology
  • Mycology
  • Molecular Biology

Background:

  • Eukaryotic cells utilize membrane traffic for organelle communication.
  • Filamentous fungi exhibit specialized membrane traffic due to high cell polarization.
  • Early endosomes (EEs) are crucial for organelle distribution and signaling in fungi.

Purpose of the Study:

  • To summarize molecular and physiological aspects of membrane traffic in filamentous fungi.
  • To highlight the role of EE dynamics in fungal cells.
  • To discuss applications related to protein secretion.

Main Methods:

  • Literature review of membrane traffic mechanisms.
  • Analysis of EE motility and function in fungi.
  • Examination of secretory pathway and protein glycosylation.

Main Results:

  • EEs exhibit dynamic long-range motility essential for fungal cell physiology.
  • Membrane traffic is integral to organelle distribution and signal transduction.
  • The secretory pathway, including glycosylation, is well-investigated for fungal protein production.

Conclusions:

  • Membrane traffic, particularly EE dynamics, plays a vital role in filamentous fungi.
  • Understanding these mechanisms offers potential for optimizing fungal cell factories for protein production.
Keywords:
Aspergillus oryzaeN-glycosylationendosomefilamentous fungisecretion

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