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Published on: March 27, 2018
Impact of postoperative complications after cardiac surgery on long-term survival
Siddharth Pahwa, Annalisa Bernabei1, Hartzell Schaff1
1Department of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Insights
Postoperative complications after cardiac surgery, such as stroke, renal failure, and pneumonia, significantly reduce long-term survival. The risk increases with the number of complications experienced by patients.
Area of Science:
- Cardiovascular Surgery
- Surgical Outcomes Research
- Patient Survival Analysis
Background:
- The long-term impact of postoperative complications following cardiac surgery requires further characterization.
- Understanding these impacts is crucial for improving patient outcomes beyond the immediate postoperative period.
Purpose of the Study:
- To determine the prevalence of postoperative complications after cardiac surgery.
- To investigate the association between these complications and long-term patient survival.
Main Methods:
- A cohort of 26,221 operative survivors undergoing coronary artery bypass grafting (CABG), valve surgery, or combined procedures between 1993 and 2019 was analyzed.
- Postoperative complications and long-term survival data were reviewed.
- Propensity-match analysis and Cox-proportional models were used to assess the impact of complications on survival.
Main Results:
- Complications occurred in 66.6% of survivors, with blood product use and atrial fibrillation being most common.
- Stroke, renal failure, and pneumonia demonstrated the strongest negative impact on long-term survival.
- An increased number of postoperative complications correlated with decreased long-term survival.
Conclusions:
- Postoperative complications following cardiac surgery have a significant and lasting effect on patient outcomes.
- Stroke, renal failure, and pneumonia are identified as key complications associated with diminished long-term survival.
Purpose:
The impact of postoperative complications on long-term survival is not well characterized. We sought to study the prevalence of postoperative complications after cardiac surgery and their impact on long-term survival.
Methods:
Operative survivors (n = 26,221) who underwent coronary artery bypass grafting (CABG) (n = 13,054, 49.8%), valve surgery (n = 8667, 33.1%) or combined CABG and valve surgery (n = 4500, 17.2%) from 1993 to 2019 were included in the study. Records were reviewed for postoperative complications and long-term survival. Propensity-match analysis was performed between patients who did and did not have a postoperative complication. The associations between postoperative complications and survival were assessed using a Cox-proportional model.
Results:
Complications occurred in 17,463 (66.6%) of 26,221 operative survivors. A total of 17 postoperative complications were analyzed. Postoperative blood product use was the commonest (n = 12,397, 47.3%), followed by atrial fibrillation (n = 8399, 32.0%), prolonged ventilation (n = 2336, 8.9%), renal failure (n = 870, 3.3%), reoperation for bleeding (n = 859, 3.3%) and pacemaker/ICD insertion (n = 795, 3.0%). Stroke (hazard ratio [HR]: 1.55; 95% confidence interval [CI]: 1.36-1.77), renal failure (HR: 1.45; 95% CI: 1.33-1.58) and pneumonia (HR: 1.23; 95% CI: 1.11-1.36) had the strongest impact on long-term survival. Long-term survival decreased as the number of postoperative complications increased.
Conclusions:
Postoperative complications after cardiac surgery significantly impact outcomes that extend beyond the postoperative period. Stroke, renal failure, and pneumonia are particularly associated with poor long-term survival.
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