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Management of COVID-19 infection in organic acidemias

Shagun Kaur1, Stephanie L Campbell1, David W Stockton1,2

  • 1Division of Genetic, Genomic, and Metabolic Disorders, Children's Hospital of Michigan, Detroit, Michigan, USA.

American Journal of Medical Genetics. Part A
|March 9, 2021
PubMed

Insights

COVID-19 infection can cause metabolic decompensation in children with inborn errors of metabolism (IEM). SARS-CoV-2 did not worsen metabolic decline beyond typical expectations for these patients.

Area of Science:

  • Infectious Diseases
  • Metabolic Disorders
  • Pediatric Health

Background:

  • The COVID-19 pandemic has had a global impact on health, with pediatric cases generally showing milder symptoms.
  • Limited research exists on Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infections in children with inborn errors of metabolism (IEM).

Observation:

  • This report details two pediatric patients with underlying metabolic disorders: propionic acidemia and glutaric aciduria type 1.
  • The patients' clinical presentations, infectious disease management, and metabolic care during SARS-CoV-2 infection are discussed.

Findings:

  • Individuals with IEM are susceptible to metabolic decompensation when infected with SARS-CoV-2.
  • The severity of metabolic deterioration from SARS-CoV-2 infection in these patients was consistent with their typical metabolic challenges.

Implications:

  • Children with inborn errors of metabolism require careful monitoring for metabolic decompensation during COVID-19 infections.
  • Understanding the interaction between SARS-CoV-2 and IEM is crucial for effective clinical management and patient outcomes.

Keywords:
COVID-19SARS-CoV-2glutaric acidemia type 1pediatricpropionic acidemia

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