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Updated: Nov 14, 2025

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
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Published on: November 10, 2013

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DNA Interaction and Cytotoxic studies on Mono/Di-Oxo and Peroxo- Vanadium (V) complexes - A Review

Saraswathi Kothandan1, Angappan Sheela1

  • 1Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, India.

Mini Reviews in Medicinal Chemistry
|March 10, 2021
PubMed

Insights

Vanadium complexes show promise as anticancer agents, targeting key cellular pathways. This review highlights vanadium (V) complexes with diverse ligands and their potential as lead compounds for cancer therapy.

Area of Science:

  • Medicinal Chemistry
  • Biochemistry
  • Pharmacology

Background:

  • Vanadium compounds (IV & V) exhibit significant biological activity, including insulin mimetic, antibacterial, antioxidant, and anticancer properties.
  • Ligand design is crucial for tailoring metal complex properties for therapeutic applications.
  • The synergistic combination of vanadium and specific ligands can yield potent drug candidates.

Purpose of the Study:

  • To review vanadium (V) complexes with various ligand systems.
  • To summarize their biological significance, particularly as anticancer lead compounds.

Main Methods:

  • Literature review of vanadium (V) complexes and their biological activities.
  • Analysis of proposed mechanistic pathways for antitumor effects.

Main Results:

  • Vanadium complexes demonstrate anticancer potential through various mechanisms.
  • Key pathways implicated include tyrosine phosphorylation, protein tyrosine phosphatases (PTPases) inhibition, and extracellular regulated kinase (ERK) pathway activation.

Conclusions:

  • Vanadium (V) complexes, modulated by diverse ligand systems, represent a promising area for anticancer drug development.
  • Further research into these complexes could lead to novel chemotherapeutic agents.
Keywords:
DNA bindingOxovanadium(V)cell cycle arrest.cytotoxicityperoxovanadiumprotein tyrosine phosphatases

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