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Factors Associated with Anticoagulation Adherence in Chinese Patients with Non-Valvular Atrial Fibrillation

Ting Song1, Xiao Xin2, Peirong Cui1

  • 1School of Nursing, Shanghai Jiaotong University, Shanghai, People's Republic of China.

Patient Preference and Adherence
|March 10, 2021
PubMed

Insights

Medication adherence in non-valvular atrial fibrillation (NVAF) patients is influenced by income, comorbidities, and self-efficacy. Higher income, fewer comorbidities, and greater self-efficacy correlate with better adherence to anticoagulants.

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Medication adherence is crucial for effective anticoagulation in non-valvular atrial fibrillation (NVAF).
  • Poor adherence increases the risk of ischemic stroke and mortality in NVAF patients.
  • Identifying factors influencing adherence is key to improving patient outcomes.

Purpose of the Study:

  • To investigate medication adherence in patients with NVAF.
  • To identify social-demographic, disease-related, and self-efficacy factors impacting adherence.
  • To inform strategies for enhancing anticoagulation therapy effectiveness and safety.

Main Methods:

  • A cohort of 170 NVAF patients on oral anticoagulation for at least 3 months was studied.
  • The Morisky Medication Adherence Scale (MGL) was used; scores <4 indicated low adherence.
  • Data collection occurred between June 2020 and September 2020 at a tertiary hospital.

Main Results:

  • 29.4% of NVAF patients exhibited low medication adherence (MGL score <4).
  • Factors associated with high adherence included higher monthly income, fewer comorbidities, and greater self-efficacy.
  • Prescription of multiple drugs (OR: 3.51), high income (OR: 7.87), absence of other diseases (OR: 8.00), and high self-efficacy (OR: 1.42) were significant predictors.

Conclusions:

  • Number of prescribed drugs, presence of comorbidities, monthly income, and self-efficacy significantly influence adherence to non-vitamin K antagonist oral anticoagulants (NOACs).
  • These findings highlight the multifactorial nature of medication adherence in NVAF.
  • Targeting these factors may improve patient adherence and reduce stroke risk.
Abstract

Keywords:
anticoagulationatrial fibrillationdeterminantsmedication adherencenon-vitamin K antagonist oral anticoagulants

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