Oral Microbial Diversity Formed and Maintained through Decomposition Product Feedback Regulation and Delayed...

Oral microbial diversity plays an important role on oral health maintenance. However, there are only few kinds of substrates available for the microbial flora in oral cavity, and it still remains unclear why oral microbial diversity can be formed and sustained without obvious competitive exclusion. Based on experimental phenomena and data, a new hypothesis was proposed, namely, the decomposition product negative feedback regulation on microbial population size and microbial delay responses including reproductive, reaction, interspecific competition, and substrate decomposition delay responses induced by oral immunity. According to hypothesis and its cellular automata (CA) model, the CA simulation results sufficiently proved that the decomposition product negative feedback regulation and four microbial delay responses could significantly alleviate the interspecific competitions and inhibit the emergence of dominant species, causing the formation and sustenance of oral microbial diversity. This study could also offer effective guidance of prevention and treatment of oral cavity diseases.