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Rapid development of seizures and PRES in a COVID-19 patient

Fabiane Santos de Lima1, Sara Klein1, Faten El Ammar1

  • 1Adult Epilepsy Center, Department of Neurology, 5841 S. Maryland Ave., MC 2030, University of Chicago, Chicago, IL 60637, United States.

Epilepsy & Behavior Reports
|March 10, 2021
PubMed

Insights

COVID-19 infection can cause neurological issues. This case highlights a patient with sickle cell disease experiencing PRES and seizures, suggesting a combined risk.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Hematology

Background:

  • Neurological dysfunction affects up to 36% of hospitalized COVID-19 patients.
  • Sickle cell disease is a risk factor for severe COVID-19 outcomes.
  • Posterior reversible encephalopathy syndrome (PRES) is a neurological condition.

Observation:

  • A patient with COVID-19 and sickle cell disease rapidly developed PRES.
  • The patient also experienced acute seizures.

Findings:

  • The co-occurrence of COVID-19 and sickle cell disease may increase the risk of PRES.
  • This combination might contribute to the elevated mortality rates observed in COVID-19 patients with sickle cell disease.

Implications:

  • Highlights potential synergistic risks between COVID-19 and sickle cell disease.
  • Suggests increased vigilance for neurological complications in this patient population.
  • Informs clinical management and research into COVID-19's neurological impact on vulnerable groups.

Keywords:
COVID-19Case reportPRESPosterior reversible encephalopathy syndromeSARS-CoV-2

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