Prothrombinase: the paradigm for membrane bound enzyme complexes; a memoir.
1College of Medicine, University of Vermont, Burlington, VT, USA. kgmann1@comcast.net.
Journal of Thrombosis and Thrombolysis
|March 10, 2021
Summary
This review details the Prothrombinase complex paradigm's development and its integration into the extrinsic pathway. It highlights key research efforts and contributors from 1968 to 2012.
Area of Science:
- Biochemistry
- Hematology
- Molecular Biology
Background:
- The Prothrombinase complex is crucial for blood coagulation.
- Understanding its pathway is essential for hemostasis research.
Purpose of the Study:
- To review the historical development of the Prothrombinase complex paradigm.
- To document its incorporation into the extrinsic pathway of coagulation.
- To summarize key research findings and contributors from 1968-2012.
Main Methods:
- Historical literature review.
- Summary of laboratory research findings.
- Identification of key research personnel.
Main Results:
- The Prothrombinase complex paradigm has evolved significantly.
- Its role within the extrinsic pathway has been clarified.
- Numerous researchers have contributed to this field.
Conclusions:
- The Prothrombinase complex paradigm is a cornerstone of coagulation research.
- Continued investigation is vital for understanding hemostasis and developing therapies.
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