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Updated: Jun 9, 2026

Two-Photon-Based Photoactivation in Live Zebrafish Embryos
Published on: December 24, 2010
Ground-State Proton-Transfer (GSPT)-Assisted Enhanced Two-Photon Uncaging from a Binol-based AIE-Fluorogenic
Biswajit Roy1, Samrat Roy2, Moumita Kundu3
1Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Abstract:
We demonstrated for the first time without any chemical modification the two-photon absorption (TPA) cross-section can be enhanced and red-shifted to the near-infrared (NIR) region by the ground-state proton-transfer (GSPT) process. Using GSPT, we developed a simple binol-based aggregation-induced emission (AIE)-fluorogenic phototrigger having a large two-photon uncaging cross-section in the "phototherapeutic window". As a proof of concept, we showed our phototrigger for the release of two different anticancer drugs in the NIR region.
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