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Probiotic Studies in Neonatal Mice Using Gavage

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

Strain inheritance and neonatal gut microbiota development: A meta-analysis.

Daniel Podlesny¹, W Florian Fricke²

¹Department of Microbiome Research and Applied Bioinformatics, University of Hohenheim, Stuttgart, Germany.

International Journal of Medical Microbiology : IJMM

|March 10, 2021

Summary

This study reveals how infant gut microbiota develops, showing delivery mode impacts composition long-term. It highlights strain sharing within families and its persistence from infancy through adulthood.

Keywords:

Birth type Cesarean section Metagenomics Microbiota maturation Neonatal microbiome Strain tracking Vaginal delivery

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Area of Science:

Microbiome research
Human gut microbial ecology
Strain-level microbial analysis

Background:

Gut microbiota structure is linked to inflammatory and metabolic disorders.
Understanding early gut microbiota development is crucial but incomplete.
Strain-level dynamics and transfer mechanisms require further investigation.

Purpose of the Study:

To comprehensively analyze the developing human gut microbiota at the strain level.
To investigate the impact of delivery mode and family contacts on microbiota composition and persistence.
To characterize microbial strain transfer and its long-term effects from infancy to adulthood.

Main Methods:

Large-scale meta-analysis of over 1900 metagenomic shotgun samples from diverse age groups.
Utilized the SameStr program for strain-level microbiota profiling and detection of microbial transfer.
Employed unsupervised network analysis based on shared strain profiles.

Main Results:

Fecal microbiota composition strongly associates with age and delivery mode up to two years.
Cesarean section delivery is linked to non-gut species and delayed microbial community transition.
Family members cluster together based on shared microbial strains, indicating transfer and persistence.
Vaginal delivery promotes greater maternal strain sharing, reduced by maternal antibiotics.
Shared strains persist through infancy and childhood, mirroring adult patterns.

Conclusions:

Provides a detailed picture of dynamic neonatal and infant gut microbiota development.
Identifies early-life taxonomic and functional differences between vaginally born and C-section infants persisting into adolescence.
Demonstrates significant strain sharing and persistence within families, influencing long-term gut microbial composition.