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Related Experiment Video

Updated: Nov 14, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Smart transformable nanomedicines for cancer therapy.

Yuequan Wang¹, Shumeng Li¹, Xinhui Wang¹

¹Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.

|March 10, 2021

Summary

Smart transformable nanomedicines offer solutions to overcome drug delivery challenges in cancer therapy. These systems exhibit size reduction, altered nanostructures, and shell detachment for improved therapeutic outcomes.

Keywords:

Cancer treatment Nanomedicine Shell detachment Size reduction Transformable nanostructures

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Last Updated: Nov 14, 2025

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Published on: June 13, 2014

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Published on: May 22, 2020

Area of Science:

Biomedical Engineering
Nanotechnology
Oncology

Background:

Nanoparticulate drug delivery systems (nano-DDS) face significant delivery challenges.
Smart transformable nano-DDS are a promising strategy to enhance nanomedicine efficacy.
Anticancer nanomedicines are a key focus in this emerging field.

Purpose of the Study:

To review advances in smart transformable nanomedicines for cancer therapy.
To outline strategies for overcoming nano-DDS delivery obstacles.
To highlight future perspectives and challenges.

Main Methods:

Summarizing smart size-reducible nanoparticles (NPs) for tumor penetration.
Discussing transformable nanostructures for various therapeutic applications.
Introducing shell-detachable nanocarriers and their triggering mechanisms.

Main Results:

Size reduction strategies include carrier degradation, protonation, and photobleaching.
Transformable nanostructures aid in tumor retention, drug resistance reversal, and metastasis inhibition.
Shell detachment can be triggered by chemical bonds, charge repulsion, or external stimuli.

Conclusions:

Smart transformable nanomedicines represent a significant advancement in overcoming nano-DDS limitations.
These systems offer diverse strategies for improved cancer treatment.
Further research is needed to address clinical translation challenges.