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Arrhythmia Risk Profile and Ventricular Repolarization Indices in COVID-19 Patients: A Systematic Review and

Alexander Edo Tondas1, Rido Mulawarman2, Monica Trifitriana2

  • 1Department of Cardiology and Vascular Medicine, Mohammad Hoesin General Hospital, Palembang, Sumatera Selatan, Indonesia. edotondas@fk.unsri.ac.id.

Journal of Infection in Developing Countries
|March 10, 2021
PubMed

Insights

COVID-19 patients show increased cardiac arrhythmia risk. Key electrocardiographic markers, including the T-peak-to-T-end (Tp-e) interval, QT dispersion (QTd), and Tp-e/QTc ratio, were significantly elevated in individuals with COVID-19.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Diagnostics

Background:

  • COVID-19 is linked to cardiac arrhythmias.
  • Electrocardiographic markers can predict arrhythmia risk in COVID-19 patients.

Purpose of the Study:

  • To investigate electrocardiographic (ECG) ventricular repolarization indices in COVID-19 patients.
  • To analyze Tp-e interval, QT dispersion (QTd), and Tp-e/QTc ratio in COVID-19.

Main Methods:

  • Systematic literature search of PubMed, EuropePMC, SCOPUS, Cochrane, and Google Scholar.
  • Meta-analysis of 2 studies including 241 patients with newly diagnosed COVID-19.
  • Primary endpoints: Tp-e interval, QTd, and Tp-e/QTc ratio up to August 2020.

Main Results:

  • The Tp-e/QTc ratio was significantly higher in the COVID-19 group (mean difference 0.02).
  • The Tp-e interval was more prolonged in COVID-19 patients (mean difference 7.76).
  • QT dispersion (QTd) was also increased in the COVID-19 group (mean difference 1.22).

Conclusions:

  • Electrocardiographic markers Tp-e/QTc, Tp-e interval, and QTd are significantly elevated in COVID-19 patients.
  • These findings suggest potential utility in assessing cardiac risk in COVID-19.
Abstract

Keywords:
COVID-19ECGSARS-CoV-2T-peak-to-T-endarrhythmiameta-analysisventricular repolarization

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