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Related Experiment Video

Updated: Nov 14, 2025

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

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Published on: June 14, 2015

Postinfarction posterobasal ventricular septal defect closure with a triple-layer patch.

Davide Pacini^1,2, Antonino Costantino¹, Daniela Votano¹

¹Division of Cardiac Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy

Multimedia Manual of Cardiothoracic Surgery : MMCTS

|March 10, 2021

Summary

This summary is machine-generated.

A novel surgical technique successfully repaired a large ventricular septal defect caused by myocardial infarction using a triple-layer pericardium-Dacron patch. This method ensures durable closure, reduces leakage, and minimizes thrombogenicity for improved patient outcomes.

Keywords:

Mechanical complications of ischemia Myocardial infarction Postinfarction ventricular septal rupture Triple layer patch repair Ventricular septal defect

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Area of Science:

Cardiovascular Surgery
Cardiac Repair Techniques
Myocardial Infarction Complications

Background:

Ventricular septal defects (VSDs) can arise as a complication of acute myocardial infarction (MI).
Large VSDs post-MI pose significant surgical challenges.
Standard repair methods may face limitations in complex cases.

Observation:

A 65-year-old patient presented with a large posterobasal VSD following extensive inferior and basal septum MI.
A novel surgical approach involving cardiac apex verticalization and ventriculotomy was employed.
A unique triple-layer patch (heterologous pericardium and Dacron) was utilized for VSD closure.

Findings:

The triple-layer patch provided complete and durable closure of the VSD.
The technique ensured resistance to suture stress and reduced the risk of leakage.
The internal pericardial surface minimized thrombogenicity, enhancing safety.

Implications:

This surgical strategy offers an effective solution for complex VSDs post-MI.
The patch design demonstrates improved safety and durability in cardiac repair.
This approach may be applicable to similar challenging cardiac defect repairs.