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Contribution of STAT3 to the pathogenesis of COVID-19

Abdollah Jafarzadeh1, Maryam Nemati2, Sara Jafarzadeh3

  • 1Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran; Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Microbial Pathogenesis
|March 10, 2021
PubMed

Insights

Signal transducer and activator of transcription-3 (STAT-3) contributes to severe COVID-19 by promoting inflammation and suppressing antiviral immunity. Targeting STAT-3 may offer a novel therapeutic strategy for treating this viral disease.

Area of Science:

  • Immunology
  • Virology
  • Molecular Biology

Background:

  • COVID-19 pathogenesis involves hyper-inflammation, cytokine storms, and immune dysregulation.
  • Signal transducer and activator of transcription-3 (STAT-3) is a key intracellular signaling molecule implicated in immune responses.

Purpose of the Study:

  • To elucidate the role of STAT-3 in COVID-19 pathogenesis.
  • To explore STAT-3 as a potential therapeutic target for COVID-19 treatment.

Main Methods:

  • Review and analysis of existing literature on STAT-3 signaling in viral infections and inflammation.
  • Discussion of STAT-3's molecular mechanisms in the context of SARS-CoV-2 infection.

Main Results:

  • STAT-3 activation exacerbates inflammatory responses and cytokine storms in severe COVID-19.
  • STAT-3 suppresses crucial antiviral interferon responses.
  • STAT-3 influences adaptive immunity, promoting Th17 responses and impairing Th1/Treg balance.
  • STAT-3 contributes to M2 macrophage polarization, lung fibrosis, and thrombosis.

Conclusions:

  • STAT-3 plays a multifaceted role in promoting COVID-19 pathogenesis.
  • Targeting STAT-3 presents a promising therapeutic avenue for managing severe COVID-19 and its complications.

Keywords:
COVID-19Immune responseInflammationPathogenesisSARS-CoV-2STAT3Treatment

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