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Quantifying a frequency modulation response biomarker in responsive neurostimulation.

Praveen Venkatesh1, Daniel Sneider1, Mohammed Danish1

  • 1Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, United States of America.

Journal of Neural Engineering
|March 10, 2021
PubMed
Summary
This summary is machine-generated.

Responsive neurostimulation (RNS) can control drug-resistant epilepsy seizures. A new method quantifies frequency modulation, a biomarker indicating RNS effectiveness, aiding personalized epilepsy treatment.

Keywords:
earth mover’s distanceepilepsyepilepsy surgeryictal frequency modulationresponsive neurostimulation

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Epilepsy Research

Background:

  • Responsive neurostimulation (RNS) treats drug-resistant focal epilepsy.
  • Limited understanding of RNS mechanisms hinders personalized therapy.
  • Ictal frequency modulation is a potential biomarker for RNS response.

Purpose of the Study:

  • Develop a quantitative method to measure ictal frequency modulation.
  • Assess this method's ability to identify RNS responders.
  • Advance personalized closed-loop therapy for epilepsy.

Main Methods:

  • Quantified frequency modulation using spectral band shifts during seizures.
  • Segmented seizure patterns and measured spectral content changes.
  • Applied squared earth mover's distance to quantify modulation from baseline.

Main Results:

  • Analyzed intracranial EEG from 13 RNS therapy patients.
  • Six patients showed expert-identified frequency modulation.
  • RNS responders had significantly larger squared earth mover's distances (13.97 × 10⁻³ ± 1.197 × 10⁻³) compared to non-responders (4.994 × 10⁻³ ± 0.732 × 10⁻³).

Conclusions:

  • The developed method quantitatively detects ictal frequency modulation.
  • This technique can differentiate RNS responders from non-responders.
  • This is a step towards optimizing RNS and personalized closed-loop epilepsy therapy.