Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

295
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
295
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

210
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
210
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

414
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
414

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma nectin-4 levels are associated with changes in executive function in patients with methamphetamine use disorder undergoing treatment.

Behavioural brain research·2026
Same author

Ethanol extract of Vanilla planifolia stem induces autophagy and alters transcriptome networks in pancreatic ductal adenocarcinoma cells.

Gene·2026
Same author

Sex-specific alterations of niacin flush pathway biomarkers in schizophrenia.

Psychoneuroendocrinology·2026
Same author

Baseline glymphatic efficiency is associated with plasma BDNF changes following rTMS: an exploratory biomarker study in mood disorders.

Psychiatry research. Neuroimaging·2026
Same author

Differential pathways to loneliness in bipolar disorder: The role of childhood adversity and social support by psychotic features.

Journal of affective disorders·2026
Same author

Development and evaluation of a predictive biomarker model based on the niacin flush pathway for differentiating schizophrenia and bipolar disorder.

Schizophrenia research·2026

Related Experiment Video

Updated: Nov 14, 2025

Hippocampal Insulin Microinjection and In vivo Microdialysis During Spatial Memory Testing
10:32

Hippocampal Insulin Microinjection and In vivo Microdialysis During Spatial Memory Testing

Published on: January 11, 2013

16.8K

Peripheral insulin sensitivity predicting cognitive function in euthymic bipolar disorder patients.

Hui Hua Chang1,2,3,4, Huai-Hsuan Tseng5,6, Wei Hung Chang5,7

  • 1Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

CNS Spectrums
|March 11, 2021
PubMed
Summary

Insulin resistance is more common in bipolar disorder (BD) patients and linked to poorer executive function. Improving insulin sensitivity may enhance cognitive performance and outcomes in BD.

Keywords:
Bipolar disorderinsulin resistanceneurocognition

More Related Videos

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

10.6K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

969

Related Experiment Videos

Last Updated: Nov 14, 2025

Hippocampal Insulin Microinjection and In vivo Microdialysis During Spatial Memory Testing
10:32

Hippocampal Insulin Microinjection and In vivo Microdialysis During Spatial Memory Testing

Published on: January 11, 2013

16.8K
Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

10.6K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

969

Area of Science:

  • Neuroscience
  • Endocrinology
  • Psychiatry

Background:

  • Insulin resistance (IR) is prevalent in bipolar disorder (BD).
  • Impaired insulin sensitivity may impact BD's course and treatment outcomes.
  • The relationship between insulin sensitivity and neurocognitive function in euthymic BD requires investigation.

Purpose of the Study:

  • To investigate differences in insulin sensitivity and executive function between BD patients and controls.
  • To explore the association between insulin sensitivity and neurocognitive trajectory in euthymic BD.

Main Methods:

  • Sixty-two BD patients and 62 matched controls were recruited.
  • Insulin sensitivity was assessed using the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR).
  • Executive function was evaluated using the Wisconsin Card-Sorting Test (WCST).

Main Results:

  • BD patients exhibited significantly higher HOMA-IR values compared to controls (P=.048).
  • BD patients showed poorer executive function on the WCST compared to controls (P<.05).
  • A significant interaction was found between BD diagnosis and HOMA-IR on WCST errors (P=.01), with higher IR correlating with worse cognitive performance in BD patients.

Conclusions:

  • Insulin sensitivity is associated with neurocognitive performance in euthymic BD patients.
  • While mechanisms are unclear, interventions targeting insulin sensitivity may improve functional outcomes in BD.
  • This study highlights a potential link between metabolic health and cognitive function in bipolar disorder.