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MicroRNA-based Regulation of Picornavirus Tropism
Published on: February 6, 2017
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Picornavirus 3C - a protease ensuring virus replication and subverting host responses.
Jiamin Yi1, Jiangling Peng1, Wenping Yang1
1State Key Laboratory of Veterinary Etiological Biology and OIE/National Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China.
Journal of Cell Science
|March 11, 2021
Summary
Picornavirus protease 3C targets host factors for viral replication and immune evasion. This review details how 3C manipulates host cell processes to cause disease.
Area of Science:
- Virology
- Molecular Biology
- Immunology
Background:
- Picornaviruses utilize conserved protease 3C for replication.
- Protease 3C interacts with host cell machinery.
- Understanding 3C's role is crucial for viral pathogenesis.
Purpose of the Study:
- To review the molecular mechanisms of picornavirus protease 3C.
- To elucidate 3C's interactions with host factors.
- To highlight 3C's role in virus-host interactions and pathogenesis.
Main Methods:
- Literature review of studies on picornavirus protease 3C.
- Analysis of molecular mechanisms of 3C function.
- Synthesis of information on 3C's interaction with host proteins and pathways.
Main Results:
- Protease 3C cleaves viral polyproteins and aids RNA replication complex assembly.
- 3C hijacks host gene expression factors to promote viral replication.
- 3C inactivates innate immunity pathways and subverts host cell death.
Conclusions:
- Picornavirus protease 3C is a key virulence factor.
- 3C manipulates host cell physiology to ensure viral survival and spread.
- Targeting 3C's functions offers potential therapeutic strategies.
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