Tissue Inhibitor of Matrix Metalloproteinase 1 Increases With Ageing and Can Be Associated With Stroke　- Nested...

Area of Science:

• Biochemistry
• Gerontology
• Cardiovascular Medicine

Background:

• Collagen accumulation in the extracellular matrix is a hallmark of aging.
• Tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) is a key regulator of matrix metalloproteinases and is implicated in aging processes.
• Understanding biomarkers associated with age-related diseases like stroke is crucial for preventative strategies.

Purpose of the Study:

• To investigate the association between TIMP-1 levels and stroke risk in a general population.
• To identify determinants of TIMP-1 levels, including age and blood pressure.
• To explore the relationship between TIMP-1 and stroke across different age groups.

Main Methods:

• A nested case-control study was conducted with 953 participants from the general population.
• Serum TIMP-1 levels were measured and analyzed in relation to stroke occurrence.
• Multiple linear regression was used to identify factors associated with TIMP-1 levels, including age and systolic blood pressure (SBP).

Main Results:

• TIMP-1 levels were found to increase with age and higher systolic blood pressure.
• A J-shaped curve relationship was observed between TIMP-1 quartiles and stroke risk.
• Subjects in the highest TIMP-1 quartile (≥89 ng/mL) exhibited a significantly higher odds ratio (OR) for stroke (OR, 1.90; P=0.023).

Conclusions:

• TIMP-1 is a potential biomarker for stroke risk, particularly in individuals over 65 years old.
• Age and systolic blood pressure are significant determinants of TIMP-1 levels.
• Further research is warranted to elucidate the causal mechanisms linking TIMP-1 to stroke pathophysiology.