Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Therapy01:28

Drug Therapy

151
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
151
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

92
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
92
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

59
Body:Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug...
59
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

904
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
904
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

81
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
81
Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

1.1K
Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low frequency blood-oxygen-level-dependent oscillations, <i>APOE4,</i> and plasma pTau<sub>217</sub>.

Journal of Alzheimer's disease : JAD·2026
Same author

HLA-DRB1*15:01 drives sex- and age-dependent microglial immune phenotypes and neuroimmune signaling.

Frontiers in immunology·2026
Same author

Cost-effectiveness of iGlarLixi vs. IDegAsp in individuals with type 2 diabetes: a BRAVO model-based evaluation.

Frontiers in public health·2026
Same author

Telehealth Utilization Patterns among Patients with Chronic Conditions Across Age, Gender, Geography, and Insurance in Arkansas.

Telemedicine journal and e-health : the official journal of the American Telemedicine Association·2026
Same author

Supporting tailored adaptive change and reinforcement for medication adherence program (STAR-MAP): Rationale and design of a randomized controlled clinical trial.

Contemporary clinical trials·2026
Same author

Joint effect of hepatic steatosis index and triglyceride glucose index on cardio-renal outcomes: a real-world study.

Journal of diabetes and metabolic disorders·2026

Related Experiment Video

Updated: Nov 14, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.7K

Medication Adherence: Expanding the Conceptual Framework.

Marie Krousel-Wood1,2, Leslie S Craig1, Erin Peacock1

  • 1Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.

American Journal of Hypertension
|March 11, 2021
PubMed
Summary
This summary is machine-generated.

Traditional interventions show modest improvements in antihypertensive medication adherence among older adults. New factors like implicit attitudes, time preferences, and structural social determinants of health are needed to improve adherence and outcomes.

Keywords:
blood pressureconceptual modelhypertensionmedication adherenceolder women and men

More Related Videos

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
09:42

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Published on: November 8, 2013

13.8K
Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

634

Related Experiment Videos

Last Updated: Nov 14, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.7K
Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
09:42

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Published on: November 8, 2013

13.8K
Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

634

Area of Science:

  • Gerontology and Geriatric Medicine
  • Health Services Research
  • Social and Behavioral Sciences

Background:

  • Interventions for antihypertensive medication adherence have yielded modest adherence improvements.
  • Translating these interventions to population-level adherence and clinical outcomes in older adults remains suboptimal.
  • Traditional barriers explain limited variance in medication adherence among older adults with hypertension.

Purpose of the Study:

  • To evaluate traditional barriers to antihypertensive medication adherence in older adults.
  • To propose an expanded conceptual framework incorporating implicit attitudes, time preferences, and structural social determinants of health (SDOH) to explain adherence variation.
  • To guide interventions for sustained improvement in medication adherence and clinical outcomes.

Main Methods:

  • Analysis of data from the Cohort Study of Medication Adherence among Older adults (CoSMO).
  • Evaluation of traditional barriers to antihypertensive medication adherence among 1,544 older adults with hypertension.
  • Assessment of adherence using pharmacy refill data (proportion of days covered) and self-reported measures (Krousel-Wood Medication Adherence Scale).

Main Results:

  • Traditional barriers explained only 6.4% of variance in pharmacy refill adherence and 14.8% in self-reported adherence.
  • Persistent low adherence rates highlight the need to explore additional factors beyond traditional barriers.
  • Implicit attitudes, time preferences, and structural SDOH are emerging determinants potentially explaining greater adherence variation.

Conclusions:

  • Traditional barriers inadequately explain medication adherence in older adults with hypertension.
  • An expanded conceptual framework including implicit attitudes, time preferences, and structural SDOH is proposed.
  • This framework can inform the development of more effective interventions to improve medication adherence and clinical outcomes in this population.