Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Caenorhabditis becei</i> recombinant inbred lines (beRILs) reveal the scope of heritable variation within a gonochoristic nematode population.

bioRxiv : the preprint server for biology·2026
Same author

Global genomic diversity of the selfing nematode <i>Caenorhabditis tropicalis</i> correlates with geography.

bioRxiv : the preprint server for biology·2026
Same author

Caenorhabditis diversity on Pohnpei, Micronesia, provides evidence that the Elegans Supergroup has its roots in the Americas and diversified in the Pacific en route to Asia.

Evolution; international journal of organic evolution·2026
Same author

Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants.

Toxicological sciences : an official journal of the Society of Toxicology·2026
Same author

<i>Caenorhabditis briggsae</i> ancestral genomic hyper-diversity contrasts with globally distributed genome-wide haplotypes.

bioRxiv : the preprint server for biology·2025
Same author

Natural variation suggests candidate genes underlying <i>Caenorhabditis elegans</i> susceptibility to diverse toxicants.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Nov 14, 2025

Detecting Protein Subcellular Localization by Green Fluorescence Protein Tagging and 4',6-Diamidino-2-phenylindole Staining in Caenorhabditis elegans
09:36

Detecting Protein Subcellular Localization by Green Fluorescence Protein Tagging and 4',6-Diamidino-2-phenylindole Staining in Caenorhabditis elegans

Published on: July 30, 2018

9.8K

Gene-level quantitative trait mapping in Caenorhabditis elegans.

Luke M Noble1,2, Matthew V Rockman2, Henrique Teotónio1

  • 1Institut de Biologie, École Normale Supérieure, CNRS 8197, Inserm U1024, PSL Research University, F-75005 Paris, France.

G3 (Bethesda, Md.)
|March 11, 2021
PubMed
Summary
This summary is machine-generated.

The Caenorhabditis elegans multiparental experimental evolution (CeMEE) panel provides a powerful resource for genetic mapping. CeMEE version 2 enhances this tool with new lines and updated simulations for trait evolution studies.

Keywords:
MPPMultiparent Advanced Generation Inter-Cross (MAGIC)Multiparental PopulationsQTLcomplex traitexperimental evolutiongenetic architecturequantitative trait

More Related Videos

Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans
08:47

Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans

Published on: July 5, 2019

10.1K
Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes
18:38

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Published on: September 25, 2013

12.3K

Related Experiment Videos

Last Updated: Nov 14, 2025

Detecting Protein Subcellular Localization by Green Fluorescence Protein Tagging and 4',6-Diamidino-2-phenylindole Staining in Caenorhabditis elegans
09:36

Detecting Protein Subcellular Localization by Green Fluorescence Protein Tagging and 4',6-Diamidino-2-phenylindole Staining in Caenorhabditis elegans

Published on: July 30, 2018

9.8K
Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans
08:47

Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans

Published on: July 5, 2019

10.1K
Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes
18:38

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Published on: September 25, 2013

12.3K

Area of Science:

  • Evolutionary biology
  • Genetics
  • Quantitative trait analysis

Background:

  • The Caenorhabditis elegans multiparental experimental evolution (CeMEE) panel is a valuable resource for studying trait evolution.
  • It comprises genome-sequenced, cryopreserved recombinant inbred lines.

Purpose of the Study:

  • To expand the CeMEE resource with new lines and populations.
  • To report the genotype and haplotype composition of CeMEE version 2.
  • To provide updated simulations for mapping quantitative trait loci (QTL).

Main Methods:

  • Expansion of the CeMEE panel with new lines and populations.
  • Genotyping and haplotype analysis of CeMEE version 2.
  • Development of additive and epistatic mapping simulations.

Main Results:

  • CeMEE version 2 includes a large set of putative de novo mutations.
  • Additive QTL explaining 4% of trait variance are detected with >80% power.
  • High recombination on chromosome arms allows for single-gene resolution mapping.

Conclusions:

  • The updated CeMEE panel is a robust resource for genetic mapping of quantitative traits.
  • Genetic variation in CeMEE populations is primarily derived from the ancestral population.
  • CeMEE version 2 facilitates high-resolution mapping of trait evolution.