Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Reproductive Cloning

Reproductive Cloning

Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Programmable mRNA 3'UTR engineering restores MHC-I and overcomes immune evasion in prostate cancer.

Nature biomedical engineering·2026

Same author

Optimization of the Nonclinical Biological Evaluation of Medical Devices Using Toxicologic Pathology Best Practices.

Advanced healthcare materials·2025

Same author

Pathology as a Core Discipline in the Biological Evaluation of Medical Devices.

International journal of toxicology·2025

Same author

SARS-CoV-2 infection induces pro-fibrotic and pro-thrombotic foam cell formation.

Nature microbiology·2025

Same author

Nrf2 Hyperactivation as a Driver of Radiotherapy Resistance and Suppressed Antitumor Immunity in Head and Neck Squamous Cell Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2025

Same author

Determining the Relationship between Delivery Parameters and Ablation Distribution for Novel Gel Ethanol Percutaneous Therapy in Ex Vivo Swine Liver.

Polymers·2024

Search research articles

Related Experiment Video

Updated: Nov 14, 2025

The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques

The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques

Published on: July 3, 2014

Bioethical, Reproducibility, and Translational Challenges of Animal Models.

Margaret Landi¹, Jeffrey Everitt², B Berridge³

¹GSK Pharmaceuticals, 1250 S Collegeville Rd, Collegeville, PA 19426, USA.

|March 11, 2021

Summary

Standardized review of animal models is lacking, hindering reproducibility and translatability in research. This study proposes recommendations to improve the review process for better scientific outcomes and ethical considerations.

Keywords:

animal model bioethical reproducibility translatability

More Related Videos

Working with Human Tissues for Translational Cancer Research

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

Related Experiment Videos

Last Updated: Nov 14, 2025

The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques

The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques

Published on: July 3, 2014

Working with Human Tissues for Translational Cancer Research

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

Area of Science:

Biomedical research
Animal models
Scientific reproducibility

Background:

Current review processes for animal model protocols lack standardization.
Inconsistent documentation of review methods challenges reproducibility and translatability in human disease research.
Poorly designed studies impede accurate harm/benefit analysis and raise ethical concerns.

Purpose of the Study:

To address the lack of standardized review for animal model protocols.
To offer recommendations for refining the review process to enhance study reproducibility and translatability.
To focus on animal models not governed by existing regulations.

Main Methods:

Review of existing literature on animal model study design and review processes.
Identification of challenges in ensuring reproducibility and translatability.
Development of recommendations for improved protocol review.

Main Results:

Absence of a prescribed stage for reviewing animal model protocols for reproducibility and translatability.
Inconsistent documentation of review methods in scientific literature.
Identification of ethical and scientific challenges arising from inadequate review.

Conclusions:

Refining the review process for animal models is crucial for improving scientific rigor.
Recommendations are provided to enhance the reproducibility and translatability of research using animal models.
Improved review practices can strengthen the scientific justification and ethical basis of animal research.