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Updated: Nov 14, 2025

Spatial and Temporal Analysis of Active ERK in the C. elegans Germline
Published on: November 29, 2016
Dynamics of ERK regulation in the processive limit
Carsten Conradi1, Nida Obatake2, Anne Shiu2
1HTW Berlin, Berlin, Germany.
Abstract:
We consider a model of extracellular signal-regulated kinase regulation by dual-site phosphorylation and dephosphorylation, which exhibits bistability and oscillations, but loses these properties in the limit in which the mechanisms underlying phosphorylation and dephosphorylation become processive. Our results suggest that anywhere along the way to becoming processive, the model remains bistable and oscillatory. More precisely, in simplified versions of the model, precursors to bistability and oscillations (specifically, multistationarity and Hopf bifurcations, respectively) exist at all "processivity levels". Finally, we investigate whether bistability and oscillations can exist together.
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