Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elevated 7B2 levels during normal human pregnancy.

U T Leonhardt1, J C Stevenson, M A Ghatei

  • 1Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom.

American Journal of Obstetrics and Gynecology
|May 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multispecies transboundary landscape connectivity in the KAZA TFCA.

Scientific reports·2026
Same author

Early warning of trends in commercial wildlife trade through novel machine-learning analysis of patent filing.

Nature communications·2024
Same author

Effects of weather and social factors on hormone levels in the European badger (Meles meles).

Zoology (Jena, Germany)·2023
Same author

Effect of hormone replacement therapy on intervertebral disc height.

Climacteric : the journal of the International Menopause Society·2023
Same author

Towards equitable conservation: Social capital, fear and livestock loss shape perceived benefit from a protected area.

Journal of environmental management·2022
Same author

Cardiometabolic health in premature ovarian insufficiency.

Climacteric : the journal of the International Menopause Society·2021

Plasma concentrations of the novel protein 7B2 significantly increase during pregnancy, peaking before delivery. This 7B2 immunoreactivity, also found in fetal blood and placenta, may play a crucial role in pregnancy.

Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Protein Chemistry

Background:

  • The protein 7B2, initially isolated from the pituitary gland, has an unknown function.
  • Circulating levels of 7B2 have not been previously studied in pregnant or postpartum women.

Purpose of the Study:

  • To measure plasma concentrations of immunoreactive 7B2 in healthy pregnant and postpartum women.
  • To compare 7B2 levels in pregnant women with nonpregnant controls.
  • To investigate the presence and origin of 7B2 in fetal blood and the placenta.

Main Methods:

  • Cross-sectional study design.
  • Measurement of plasma concentrations of immunoreactive 7B2 using established assays.
  • Chromatographic analysis of plasma and placental extracts.

Related Experiment Videos

Main Results:

  • Significantly elevated plasma 7B2 concentrations were observed throughout pregnancy compared to nonpregnant controls (p < 0.01).
  • 7B2 levels peaked in late pregnancy (36-40 weeks) and decreased rapidly postpartum, normalizing within 4-6 weeks.
  • High concentrations of 7B2-like immunoreactivity were detected in fetal umbilical artery and vein plasma, and 7B2 was extractable from the placenta.

Conclusions:

  • Plasma 7B2 immunoreactivity is significantly altered during human pregnancy.
  • Fetal blood exhibits high levels of 7B2, suggesting fetal origin.
  • The placenta contains 7B2, and this protein may have an important, yet undefined, role in pregnancy.