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Related Experiment Videos

The infant corneal endothelium.

L Speedwell1, P Novakovic, E S Sherrard

  • 1Institute of Child Health, London, England.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|June 1, 1988
PubMed
Summary
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Specular microscopy in infants revealed a regular corneal endothelium mosaic. Cell density varied, decreasing in the first year possibly due to corneal growth, not cell loss, with unclear evidence of endothelial mitoses.

Area of Science:

  • Ophthalmology
  • Corneal Science
  • Cell Biology

Background:

  • The corneal endothelium is crucial for maintaining corneal clarity.
  • Understanding endothelial cell development in infants is vital for predicting long-term corneal health.
  • Previous studies on infant corneal endothelium are limited.

Purpose of the Study:

  • To characterize the in vivo corneal endothelium in infants under one year old.
  • To assess changes in endothelial cell density and morphology during early development.
  • To investigate the potential mechanisms behind observed changes in cell density.

Main Methods:

  • Specular microscopy was performed on 48 eyes of 31 healthy infants (<1 year old).
  • Corneal endothelial cell density and morphology were analyzed.

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  • Follow-up examinations were conducted on five eyes to track changes over time.

    • Main Results:

    • A regular mosaic of small endothelial cells was observed in all infants.
    • Significant variation in cell population density was noted among individuals.
    • A reduction in cell population density was observed during the first year of life.
    • Morphologic signs suggestive of endothelial mitoses were present but inconclusive.

    Conclusions:

    • Infant corneal endothelium exhibits a regular mosaic pattern.
    • The observed decrease in cell density during infancy is likely attributable to corneal growth rather than true cell loss.
    • Further research is needed to definitively confirm the presence and role of endothelial mitoses in infant corneal development.