Related Experiment Videos
Maprotiline poisoning in a child
R Peverini1, S Ashwal, E Petry
1Department of Pediatrics, Loma Linda University School of Medicine, CA 92350.
Insights
Maprotiline overdose in a child caused severe seizures and temporary neurological issues. Prompt medical care led to a full recovery, highlighting the importance of timely intervention for antidepressant toxicity.
Area of Science:
- Toxicology
- Pediatric Neurology
- Pharmacology
Background:
- Maprotiline is a tetracyclic antidepressant with potential for toxicity in overdose.
- Pediatric poisoning cases require careful assessment and management.
- Seizures are a known complication of antidepressant toxicity.
Observation:
- A 6-year-old girl experienced prolonged tonic-clonic seizures and generalized convulsions.
- Serum drug screening confirmed maprotiline ingestion with an estimated dose of 12 mg/kg.
- Initial neurological impairment was noted upon hospital discharge.
Findings:
- The patient's seizures and neurological deficits resolved over time.
- Maprotiline toxicity can manifest with significant central nervous system effects.
- Successful management of maprotiline overdose is achievable with appropriate care.
Implications:
- This case underscores the critical need for prompt diagnosis and treatment of maprotiline overdose in children.
- Understanding the clinical presentation and management strategies is vital for pediatricians and toxicologists.
- Early intervention can lead to favorable neurological outcomes in pediatric antidepressant poisoning.
Abstract:
A 6-year-old girl presented with tonic-clonic seizures and generalized convulsions lasting several minutes. A serum drug screen revealed maprotiline, and the estimated intake was 12 mg/kg. Despite initial neurologic impairment on discharge, follow-up 6 months later showed normal neurologic function in the patient. This report describes that case and discusses the toxicity associated with maprotiline and its management.