Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Maprotiline poisoning in a child.

R Peverini1, S Ashwal, E Petry

  • 1Department of Pediatrics, Loma Linda University School of Medicine, CA 92350.

The American Journal of Emergency Medicine
|May 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of ART on pregnancies in California: an analysis of maternity outcomes and insights into the added burden of neonatal intensive care.

Journal of perinatology : official journal of the California Perinatal Association·2014
Same author

Recent advances in the development of practice parameters: The vegetative state.

NeuroRehabilitation·2014
Same author

Delayed increase of astrocytic aquaporin 4 after juvenile traumatic brain injury: possible role in edema resolution?

Neuroscience·2012
Same author

Evidence-based guideline update: medical treatment of infantile spasms [RETIRED]. Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society.

Neurology·2012
Same author

So what? Does the test lead to improved health outcomes?

Neurology·2012
Same author

Evidence report: Genetic and metabolic testing on children with global developmental delay [RETIRED]: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society.

Neurology·2011
Same journal

Diagnostic accuracy of emergency department triage systems for predicting clinical severity: A systematic review and meta-analysis of five-level triage scales.

The American journal of emergency medicine·2026
Same journal

Methanol toxicity from inhalational abuse of a methyl acetate-containing nail polish remover.

The American journal of emergency medicine·2026
Same journal

Regarding strategies, feasibility of implementations and results of HIV screening in emergency departments.

The American journal of emergency medicine·2026
Same journal

Rocuronium dosing for rapid sequence intubation: A retrospective analysis in ED and ICU settings.

The American journal of emergency medicine·2026
Same journal

Clinical features of adults with undiagnosed acute leukemia in the emergency department: A descriptive study.

The American journal of emergency medicine·2026
Same journal

Occult intraperitoneal gynecological hemorrhage: An under-evaluated source of hemoperitoneum after blunt trauma.

The American journal of emergency medicine·2026
See all related articles

Maprotiline overdose in a child caused severe seizures and temporary neurological issues. Prompt medical care led to a full recovery, highlighting the importance of timely intervention for antidepressant toxicity.

Area of Science:

  • Toxicology
  • Pediatric Neurology
  • Pharmacology

Background:

  • Maprotiline is a tetracyclic antidepressant with potential for toxicity in overdose.
  • Pediatric poisoning cases require careful assessment and management.
  • Seizures are a known complication of antidepressant toxicity.

Observation:

  • A 6-year-old girl experienced prolonged tonic-clonic seizures and generalized convulsions.
  • Serum drug screening confirmed maprotiline ingestion with an estimated dose of 12 mg/kg.
  • Initial neurological impairment was noted upon hospital discharge.

Findings:

  • The patient's seizures and neurological deficits resolved over time.
  • Maprotiline toxicity can manifest with significant central nervous system effects.

Related Experiment Videos

  • Successful management of maprotiline overdose is achievable with appropriate care.

    • Implications:

    • This case underscores the critical need for prompt diagnosis and treatment of maprotiline overdose in children.
    • Understanding the clinical presentation and management strategies is vital for pediatricians and toxicologists.
    • Early intervention can lead to favorable neurological outcomes in pediatric antidepressant poisoning.