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Selaginellin Derivatives from Selaginella tamariscina and Their Upregulating Effects on Low-Density Lipoprotein
Sunmin Woo1, Hee-Sung Chae1, Jinwoong Kim1
1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
Abstract:
Two new dimeric selaginellins, diselaginellins C and D (1 and 2), a new unusual derivative, selapiginellin A (4), a new selaginpulvilin U (5), and a known derivative, diselaginellin A (3), were isolated from Selaginella tamariscina (P. Beauv.) Spring. Among these compounds, selapiginellin A (4) is the first naturally occurring compound comprising an ether-linked dimer of a selaginellin and a selaginpulvilin. The absolute configurations of 1, 2, and 4 were elucidated by spectroscopic data analyses. Compound 5 was found to regulate mRNA expression of the low-density lipoprotein receptor (LDLR) gene and LDLR-related genes.
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